2024级研究生：

《检验医学进展》课程第四次讲座具体安排如下，请大家提早10分钟到场，谢谢！

    讲座主题：Novel regulatory mechanisms of mitophagy by targeting PINK1, from transcription to post-translational modifications

    主讲人：Dr. Han-Ming Shen

    时间：2024年12月19日下午3:00

    地点：温州医科大学茶山校区同济楼6A107

    讲座亮点：

     Mitophagy is a selective form of autophagy for removal or clearance of damaged mitochondria via the autophagy-lysosome pathway. Among various mitophagy regulatory mechanisms, PINK1, a protein kinase, and Parkin, an E3 ligase, are two critical players in control of mitophagy, with important implications in neurodegenerative disorders such as Parkinson's disease (PD). In our recent studies, we aimed to investigate the upstream regulatory mechanisms of PINK1. I will present some of our recent work including unpublished data, including i) the transcriptional regulation of PINK1 by SMAD3, ii) glucose metabolism in regulation of mitophagy by targeting G6PD, a key enzyme in the pentose phosphate pathway (PPP), and iii) post-translational modifications (PTMs) of PINK1 such as O-GlcNAcylation. Our results provide a deeper insight into the molecular mechanisms in control of PINK1, the guardian of mitochondria and lay foundation for development of novel interventional strategies in PINK1 and mitophagy-related human diseases such as neurodegeneration and cancer.

    主讲人简介：

    Dr. Han-Ming Shen is currently a Chair Professor and Associate Dean (Teaching), Faculty of Health Sciences, University of Macau, and a visiting Professor, Yong Loo Lin School of Medicine, National University of Singapore (NUS). He received his Bachelor of Medicine (1985), Master of Medicine (1988) and PhD (1996) from Zhejiang Medical University and National University of Singapore, respectively. He also received his postdoc training in National Cancer Institute (NCI), National Institutes of Health (NIH). His research is focused on the autophagy-lysosome pathway, mitophagy, as well as on glucose metabolism in cancer cell biology. Dr. Shen has published more than 250 papers, with more than 45,000 citations and H-index at 104 (Google scholar). Currently, he serves as the Associate Editor for Autophagy, and as member of editorial board for several other journals such as Life Metabolism, Burns & Trauma and Aging Cell.

温州医科大学研究生院

2024年12月16日