2024级研究生：

《检验医学进展》课程第五次讲座具体安排如下，请大家提早10分钟到场，谢谢！

讲座主题：Next-Generation Pathogen Detection: Harnessing Aptamers for Rapid and Precise Diagnostics

主讲人：李应福教授

时间：2024年12月20日下午14:30

地点：温州医科大学茶山校区求新楼报告厅

讲座亮点：

Rapid and reliable detection of infectious pathogens is crucial for safeguarding public health, enabling prompt diagnoses, and preventing disease outbreaks. However, existing diagnostic tools often fall short in speed, simplicity, and adaptability for point-of-care (POC) use, particularly in resource-limited settings. Aptamers—synthetic single-stranded nucleic acids designed to bind specific targets with exceptional affinity and specificity—are revolutionizing diagnostics by offering advantages over traditional antibodies, such as superior chemical stability, ease of synthesis and modification, and compatibility with various signal amplification and transduction methods. In this presentation, I will explore my group’s advancements in creating aptamer-based detection platforms for critical pathogens like SARS-CoV-2, influenza A virus, norovirus, Escherichia coli, Salmonella, Legionella pneumophila, and Clostridioides difficile. Through state-of-the-art aptamer selection techniques, we have identified high-performing aptamers tailored for these pathogens. Collaborative efforts with interdisciplinary teams at McMaster University have enabled the development of practical diagnostic tools, including colorimetric assays, electrochemical sensors, and paper-based biosensors. These systems deliver rapid, accurate, and cost-effective results by combining aptamer functionality with innovative signal transduction strategies, allowing direct pathogen detection in food and clinical samples without extensive preprocessing. I will also highlight our efforts to enhance the sensitivity and robustness of these platforms, making them viable for real-world applications, particularly in low-resource environments. By leveraging the remarkable properties of aptamers, our work aims to bridge critical gaps in pathogen detection technology, paving the way for next-generation diagnostics that will strengthen global health and safety.

主讲人简介：

Dr. Yingfu Li is a Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University. He earned his Ph.D. in Biochemistry from Simon Fraser University in 1997, where his doctoral work earned him the prestigious Governor General’s Academic Gold Medal and the Natural Sciences and Engineering Research Council of Canada (NSERC) Doctoral Prize. He completed his postdoctoral research at Yale University from 1997 to 1999, supported by a fellowship from the Medical Research Council of Canada.

Dr. Li joined McMaster University in 1999 as an Assistant Professor and was promoted to Full Professor in 2010. His research focuses on functional nucleic acids, and he has authored approximately 250 research papers, review articles, and book chapters. He has held editorial positions as an Associate Editor for the Journal of Molecular Evolution and as Co-Editor-in-Chief of Advanced Agrochem.

Dr. Li has received numerous honors, including a Canada Research Chair, the New Investigator Award from the Canadian Institutes of Health Research (CIHR), the Premier’s Research Excellence Award from the Government of Ontario, and the McBryde Medal from the Canadian Society of Chemistry.

温州医科大学研究生院

2024年12月16日