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讲座主题：Mitochondrial targeting by bacterial porins
主讲人：Stijn van der Veen教授
时间：2026年10月19日上午10:00
地点：温州医科大学茶山校区生物医药科研大楼二楼报告厅
讲座亮点：
Bacterial porins are classically viewed as structural components of the bacterial outer membrane, yet accumulating evidence reveals that they act as potent mitochondrial-targeting virulence factors. This lecture presents a conserved mechanism by which bacterial porins are delivered to host epithelial cell mitochondria, ultimately triggering mitophagy. Central to this process is an HSP chaperone that both delivers porins to mitochondria and scaffolds RNF213 for their ubiquitination. These findings establish bacterial porin-induced mitophagy as a conserved host-pathogen interaction with broad implications for bacterial intracellular survival, host cell fate, and the development of novel therapeutic and vaccine strategies.
细菌孔蛋白传统上被视为细菌外膜的结构组分，但越来越多证据表明，它们是靶向线粒体的强效毒力因子。本讲座介绍一种保守机制：细菌孔蛋白经该机制被递送至宿主上皮细胞线粒体，最终触发线粒体自噬。该过程的核心是一种 HSP 分子伴侣，它既将孔蛋白递送至线粒体，又为 RNF213 提供支架，以介导孔蛋白的泛素化。这些发现确立了细菌孔蛋白诱导的线粒体自噬是一种保守的宿主-病原体相互作用，对细菌胞内存活、宿主细胞命运以及新型治疗和疫苗策略的开发具有广泛意义。
主讲人简介：
Dr. van der Veen is Professor in the Department of Microbiology at the Zhejiang University School of Medicine. He is Adjunct Professor at the Department of Infectious Diseases of the Second Affiliated Hospital and at the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases at the First Affiliated Hospital of Zhejiang University. He is also the Founding Executive Editor of the China-based international journal Infectious Microbes & Diseases. In 2015 he was elected as a Zhejiang Province overseas high talent and in 2023 he received the Xihu Friendship award for outstanding contributions to Zhejiang Province academic development and education. He has published more than 80 papers in SCI authoritative journals such as Nat Commun, Nat Rev Microbiol, Autophagy, Emerg Microbes Infect, NPJ Vaccines, ACS Cent Sci and PLoS Path, including 3 cover articles, which have accumulated more than 5,000 citations. His research focusses on bacterial pathogens, including host-microbe interactions, vaccine development and drug resistance. Website: https://person.zju.edu.cn/svdveen
Stijn van der Veen 博士是浙江大学医学院微生物学系教授。他兼任浙江大学医学院附属第二医院感染性疾病科以及浙江大学医学院附属第一医院传染病诊治国家重点实验室的兼职教授。他还是中国主办的国际期刊《Infectious Microbes & Diseases》的创刊执行主编。2015年，他入选浙江省海外高层次人才；2023年，他荣获西湖友谊奖，以表彰其为浙江省学术发展和教育作出的杰出贡献。他已在 Nat Commun、Nat Rev Microbiol、Autophagy、Emerg Microbes Infect、NPJ Vaccines、ACS Cent Sci 和 PLoS Path 等 SCI 权威期刊发表论文80余篇，其中包括3篇封面文章，累计被引用超过5000次。他的研究聚焦于细菌病原体，包括宿主-微生物相互作用、疫苗研发和耐药性。
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温州医科大学研究生院
2026年10月12日
